Sophie Yacoub

Infectious Diseases Physician and Dengue Research Group lead at OUCRU-Vietnam

Sophie is the Dengue Research Group lead at OUCRU-Vietnam, appointed in 2018. She’s a Physician in Infectious Diseases and General Medicine and holds an honorary Consultant appointment at London North West University Healthcare NHS Trust in the UK. She holds a PhD from Imperial College London and an MSc from the London School of Hygiene and Tropical Medicine.

Dengue continues to cause a major public health burden in Vietnam and globally. While most clinical cases resolve spontaneously, a proportion will develop severe manifestations, including bleeding, organ impairment, and capillary leakage sometimes leading to cardiovascular collapse. As yet, no antiviral agents or adjunctive therapies have been found to alter disease outcomes in dengue.

The focus of the group is on translational clinical research to address some of the major questions and unmet needs in the dengue field, with the overall aim of impacting dengue management and improving clinical outcomes.

Some key research areas include:

  • Pathogenesis studies: Investigating the mechanism underlying the capillary leak in severe dengue.
  • Cardiovascular monitoring and fluid management trials.
  • Immunology studies: Investigating mechanisms of immunopathology in severe dengue, through collaborations with Oxford University and DUKE-NUS, Singapore.
  • Innovations: Utilizing state-of-the-art technology and smart devices for risk prediction. Through collaborations with Imperial College London, we are setting up a platform for testing innovative technologies for improving dengue diagnostics and patient management.
  • Clinical trials: of novel host-directed therapeutics, focusing on patients at higher risk of developing severe disease.
  • Dengue virus transmission dynamics: through Monash University, Australia.
Lectures by Sophie Yacoub

Dengue

a review

Critical Care Nursing / Infectious Diseases

Dengue

a review

Critical Care Medicine / Infectious Diseases

Dengue

a review

Rural Healthcare Clinic / Infectious Diseases