Severe anaemia is a common and life-threatening cause of admission in children in sub-Saharan Africa(sSA) ~ 10% will die in hospital, and ~ 12% die 6 months post-discharge l. Whilst blood transfusions are an important treatment for severe anaemia, scientific evidence to guide doctors on how much blood to give children, or which children require it is poor. The TRACT trial showed that children with complicated severe anaemia (Hb <4g/dl or 4-6g/dl with severity signs) who do not have a fever require a larger volume of blood transfusion (30mls/kg whole blood) than current WHO guidelines recommend- halving mortality. Conversely, for children with a high temperature, guideline-recommendations (20mls./kg) are correct. The TRACT trial also showed that children with uncomplicated severe anaemia (no severity signs, haemoglobin 4-6g/dl) do not require an immediate transfusion, as long as they are closely monitored for signs of complications, or their haemoglobin levels dropping, and receive a transfusion at that point.
Critical Care Doctors
Experienced or advanced Critical Care Nurses
Upon completion of this activity, you should be able to:
1 November 2020
31 October 2023
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