Acute Muscle Wasting in the ICU

A review of the literature

The lecture duration is 28min.

0.5 CPD Points, 0.5 CEUs, 0.5 CME credits approval pending.
Accredited by CPDUK, CBRN and Provider Pending.

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Zudin Puthucheary
Senior Lecturer in Critical Care at the William Harvey Research Institute, London
Lecture Summary

Acute muscle wasting occurs rapidly in the critically ill patient, at rates of 2-3% per day, and is associated with levels of organ failure. Muscle wasting is associated with adverse outcomes at all stages of critical illness and critical illness recovery, affecting mortality up to 1 year later. Altered muscle protein homeostasis (and specifically depressed muscle protein synthesis) underpins this process and is in turn underpinned by bioenergetic failure and intramuscular inflammation. This talk will cover the underpinning biology, the potential role of exercise and nutrition in amelioration and treatment, and several ongoing trials in the field of acute muscle wasting.

Target Audience

Critical Care Doctors
Experienced or advanced Critical Care Nurses

Learning Objectives:

Upon completion of this activity, you should be able to:

  • Understand the physiology underpinning acute muscle wasting
  • Understand the modulators of muscle protein homeostasis
  • Interpret future trials of exercise and nutrition to treat functional disability
  • Describe ongoing clinical trials in the field

None.