ICU Delirium: Pathophysiology, Assessment, and Management

Dr. Elizabeth Papathanassoglou

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Lecture overview

This talk will highlight current advances in the pathophysiology of ICU delirium, including neuroinflammation, oxidative stress, and dysregulation of circadian rhythms and HPA axis. Key pathophysiological mechanisms will be linked with current evidence-based recommendations for the assessment, prevention and treatment of ICU delirium, with emphasis on evidence on non-pharmacologic interventions. Data on epidemiology and approaches to improve long-term outcomes will be presented, and gaps in the literature and practice implications will be discussed. 

Learning Objectives:
By the end of this lecture, the attendee will be able to:

  1. Identify the risk factors of ICU delirium. 
  2. Identify key pathophysiological mechanisms implicated in ICU delirium. 
  3. Identify and compare ICU delirium assessment tools.
  4. Identify the long-term outcomes of ICU delirium. 
  5. Identify evidence-based approaches to the prevention of ICU delirium. 

This lecture is equal to 1 CE Contact Hour, 1 CPD Hour, and 1 AMA PRA Category 1 Credit


Additional CME Info

Release Date: February 1, 2020, Termination Date: January 31, 2023

Accreditation: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of EB Medicine and Continulus. EB Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation: EB Medicine designates this internet enduring material for a maximum of 1 AMA PRA Category 1 Credit™ per lecture. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Commercial Support: This activity received no commercial support.

Earning Credit: In order to earn CME credit, the participant must take the pre-test, listen to the lecture, take the CME post-test, and complete the post-test evaluation.

Duration 1 hour(s).

Lecture speaker

Dr. Elizabeth Papathanassoglou

Dr. Papathanassoglou is an Associate Professor, Faculty of Nursing, University of Alberta, Canada. She is exploring the effects of non-pharmacological, integrative interventions and stress responses in critical care. She received her BSc from the University of Athens, Greece, her PhD from the University of Rochester, NY, USA, and post-doctoral training as a research fellow at Harvard Medical School, Boston, MA, USA. She has over 150 publications in peer-reviewed journals. Her work has received over 3,020 international citations (h-index: 29). She has delivered 64 invited lectures at international and national conferences and has presented another 230 papers at conferences. She is Ambassador of the World Federation of Critical Care Nurses (WFCCN) 2015-2020, WFCCN’s representative to the Global Sepsis Alliance Network and co-editor of CONNECT: The World of Critical Care Nursing, The official journal of WFCCN. She has 20 years of teaching experience as a faculty member.


CME Faculty Disclosure: It is the policy of EB Medicine to ensure objectivity, balance, independence, transparency, and scientific rigor in all CME-sponsored educational activities. All faculty participating in the planning or implementation of a sponsored activity are expected to disclose to the audience any relevant financial relationships and to assist in resolving any conflict of interest that may arise from the relationship. In compliance with all ACCME Essentials, Standards, and Guidelines, all faculty for this CME activity were asked to complete a full disclosure statement. The speaker did not report any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) discussed in this educational presentation.