Susceptibility to sepsis, flu and COVID-19: critically ill patients are abnormal hosts

Dr. Kenneth Bailie

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Lecture overview

Learning Objectives:
By the end of this lecture, the attendee will be able to:

  1. Describe the evidence for inherited susceptibility to critical illness in infection.
  2. Define key terms including phenotype and genotype.
  3. Understand the scale of the human genome and variation within it.
  4. Describe the analogous nature of new terms describing sub-syndromes and diseases.

This lecture is equal to 1 CE Contact Hour, 1 CPD Point, and 1 AMA PRA Category 1 Credit

 

Additional CME Info

Release Date: February 1, 2020, Termination Date: January 31, 2023

Accreditation: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of EB Medicine and Continulus. EB Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation: EB Medicine designates this internet enduring material for a maximum of 1 AMA PRA Category 1 Credit™ per lecture. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Commercial Support: This activity received no commercial support.

Earning Credit: In order to earn CME credit, the participant must take the pre-test, listen to the lecture, take the CME post-test, and complete the post-test evaluation.

Duration 1 hour(s).

Lecture speaker

Dr. Kenneth Bailie
MD, BSc(Hons), MBChV, PhD

Dr. Kenneth Baillie graduated from the University of Edinburgh with a BSc(Hons) in Physiology in 1999 and MBChB in 2002. He completed basic training in medicine in Glasgow, and in anaesthesia in Edinburgh. During this time he led a series of high altitude research projects in Bolivia, and founded a high-altitude research charity. He was appointed as a clinical lecturer on the ECAT (Edinburgh Clinical Academic Track) at the University of Edinburgh in 2008, and completed a Wellcome Trust-funded PhD in statistical genetics in 2012. He was awarded a Wellcome-Beit Prize Intermediate Clinical Fellowship in 2013. After completing clinical training in 2014 he worked as a visiting scientist at the Broad Institute of Harvard and MIT, before returning to the Roslin Institute, University of Edinburgh to establish a research program in translational applications of genomics in critical care medicine. He works as a consultant in the intensive care unit at the Royal Infirmary, Edinburgh.

Dr. Baillie's research interest is the genetics of host susceptibility to severe infection. He led the GenISIS (Genetics of Influenza Susceptibility in Scotland) study and the host genetics component of the MOSAIC (Mechanisms of Severe Influenza Consortium) study. In his role as working group chair for genomics, pathogenesis and pharmacology for the International Severe Acute Respiratory Infection Consortium (ISARIC), he led the development of an integrated biological sampling protocol for use in outbreaks, which is supported by the World Health Organisation and has been adopted in many countries throughout the world.

Dr. Baillie's research is focused on using genomics and transcriptomics to better understand and treat critical illness. The fundamental problem is the lack of treatments to stop people dying from severe infections - a syndrome known as sepsis. We believe that a functional genomics approach can lead us to biological processes that might be amenable to treatment. Much of his work focuses on specific infections, such as influenza. He leads the GenOMICC (Genetics of Mortality in Critical Care) Study.

Dr. Ballie is currently highly involved in COVID-19 research.

To find out more, visit: www.baillielab.net

 

CME Faculty Disclosure: It is the policy of EB Medicine to ensure objectivity, balance, independence, transparency, and scientific rigor in all CME-sponsored educational activities. All faculty participating in the planning or implementation of a sponsored activity are expected to disclose to the audience any relevant financial relationships and to assist in resolving any conflict of interest that may arise from the relationship. In compliance with all ACCME Essentials, Standards, and Guidelines, all faculty for this CME activity were asked to complete a full disclosure statement. The speaker did not report any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) discussed in this educational presentation. 

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