Acute (Fulminant) Hepatic Failure

Professor Constantine Karvellas

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Your first lecture is FREE

16 March 2021 - 10:00 PM (GMT)

Lecture overview

Acute liver failure (ALF) is a rare syndrome resulting from an acute insult to the liver in patients without known underlying chronic liver disease. It is characterized by loss of synthetic function in the form of jaundice and coagulopathy and development of hepatic encephalopathy. Multiorgan-failure (MOF) eventually develops. Significant improvements in outcome have occurred over the last 50 years, resulting not only from incremental improvements in specialist critical care and a step-change following the introduction of transplantation for this indication, but also better and more effective treatment started early at the site of first presentation.

Learning Objectives:
By the end of this lecture, the attendee will be able to:

  1. Understand the definition of Acute Liver Failure. 
  2. Review evidence for neuroprotective strategies. 
  3. Review the potential benefits of extracorporeal support including continuous renal replacement therapy.
  4. Review challenges in prognostication and the potential role for novel biomarkers.

This lecture is equal to 1 CE Contact Hour, 1 CPD Point, and 1 AMA PRA Category 1 Credit

Live webinar time:
Chicago - Tue 16th Mar 2021 at 5pm
London - Tue 16th Mar 2021 at 10pm
Sydney - Wed 17th Mar 2021 at 9am

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If you can't make the live recording, don't worry, the recording will be available shortly after


Additional CME Info

Release Date: February 1, 2020, Termination Date: January 31, 2023

Accreditation: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of EB Medicine and Continulus. EB Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation: EB Medicine designates this internet enduring material for a maximum of 1 AMA PRA Category 1 Credit™ per lecture. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Commercial Support: This activity received no commercial support.

Earning Credit: In order to earn CME credit, the participant must take the pre-test, listen to the lecture, take the CME post-test, and complete the post-test evaluation.

Duration 1 hour(s).

Lecture speaker

Professor Constantine Karvellas

Dr. Constantine (Dean) Karvellas is a Professor of Medicine (Critical Care Medicine and Gastroenterology/Hepatology) at the University of Alberta and an Adjunct Professor in the School of Public Health Sciences. He has been an attending intensivist in the E. Garner King General Systems Intensive Care Unit since 2009 and is involved with the Liver Transplant Program as a Hepatologist.

Prof. Karvellas is a co-investigator in the NIH-funded United States Acute Liver Failure Study Group (US ALFSG). He is a member of Society of Critical Care Medicine (SCCM) Liver Management Task Force. He is an Associate Editor of the Journal of Hepatology and the American Journal of Transplantation.

Prof. Karvellas’ publications reflect his interests in acute liver failure (ALF), acute on chronic liver failure (ACLF), liver transplantation and extracorporeal liver support.


CME Faculty Disclosure: It is the policy of EB Medicine to ensure objectivity, balance, independence, transparency, and scientific rigor in all CME-sponsored educational activities. All faculty participating in the planning or implementation of a sponsored activity are expected to disclose to the audience any relevant financial relationships and to assist in resolving any conflict of interest that may arise from the relationship. In compliance with all ACCME Essentials, Standards, and Guidelines, all faculty for this CME activity were asked to complete a full disclosure statement. The speaker did not report any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) discussed in this educational presentation.