What clinicians should know about inflammation in sepsis

Professor Didier Payen

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Lecture overview

Inflammation is the cornerstone of almost all life-threatening conditions motivating ICU admission. This lecture will try to give a picture of the inflammatory response putting on scene the major actors of the play. Integrating their interactions, the sepsis will be used as an example to demonstrate the kinetic of inflammation and the potential to intervene with drugs to modulate the host response facing pathogens. The recent SARS-Cov-2 pandemic is a perfect example of the role of the host response to the virus as a key determinant of the clinical presentation, acquired specific immunity, and strategy for vaccine development.

Learning Objectives:
By the end of this lecture, the attendee will be able to:

  1. Describe the global picture of inflammation.
  2. Know the different components of inflammation and immune factors.
  3. Understand the kinetics of the immune response after the hit.
  4. Being able to propose some important routine and more specific biomarkers to become classic in the near future.
  5. Understand the potential targets for immune modulation.

This lecture is equal to 1 CE Contact Hour, 1 CPD Point, and 1 AMA PRA Category 1 Credit

 

 

Additional CME Info

Release Date: February 1, 2020, Termination Date: January 31, 2023

Accreditation: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of EB Medicine and Continulus. EB Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation: EB Medicine designates this internet enduring material for a maximum of 1 AMA PRA Category 1 Credit™ per lecture. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Commercial Support: This activity received no commercial support.

Earning Credit: In order to earn CME credit, the participant must take the pre-test, listen to the lecture, take the CME post-test, and complete the post-test evaluation.

Duration 1 hour(s).

Lecture speaker

Professor Didier Payen

Dr. Didier Payen de la Garanderies is Professor (exceptional class) of Anaesthesiology and Intensive Care at the University Paris 7. Prof. Payen graduated as a medical doctor in 1982 from the University of Medicine of Nantes in France. In 1986, he became a specialist in Anaesthesia and Intensive Care. He achieved his PhD in human biology in 1988 on “Circulatory consequences of positive pressure breathing”. He became full Professor of Anaesthesiology and Intensive Care in 1997 and acted as Chairman of the Department of Anaesthesiology and Intensive Care at the University Paris 7. In 1999, Prof. Payen spent three years as Professor of Anaesthesiology and Critical Care at McGill University in Montreal, Canada.

Prof. Payen’s research has always focused on the understanding of pathophysiology, with particular emphasis on the immune response in sepsis, ARDS, haemodynamic monitoring and cardiovascular physiology, Acute Kidney Injury and Brain injury.

Prof. Payen is a creator. He has published > 400 articles and has several patents for devices. He has actively contributed in the development of European academic excellence. His scientific approach enables him to establish new concepts.

CME Faculty Disclosure: It is the policy of EB Medicine to ensure objectivity, balance, independence, transparency, and scientific rigor in all CME-sponsored educational activities. All faculty participating in the planning or implementation of a sponsored activity are expected to disclose to the audience any relevant financial relationships and to assist in resolving any conflict of interest that may arise from the relationship. In compliance with all ACCME Essentials, Standards, and Guidelines, all faculty for this CME activity were asked to complete a full disclosure statement. The speaker did not report any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) discussed in this educational presentation.  

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